I'm trying to remove the sub string _x that is located in the end of part of my df column names.

Sample df code:

import pandas as pd

d = {'W_x': ['abcde','abcde','abcde']}
df = pd.DataFrame(data=d)

df['First_x']=[0,0,0]
df['Last_x']=[1,2,3]
df['Slice']=['abFC=0.01#%sdadf','12fdak*4%FC=-0.035faf,dd43','FC=0.5fasff']

output:

     W_x  First_x Last_x                 Slice
0  abcde      0     1                   abFC=0.01
1  abcde      0     2  12fdak*4%FC=-0.035faf,dd43
2  abcde      0     3                 FC=0.5fasff

Desired output:

       W  First  Last                       Slice
0  abcde      0     1                   abFC=0.01
1  abcde      0     2  12fdak*4%FC=-0.035faf,dd43
2  abcde      0     3                 FC=0.5fasff

I usually use @cs95 way but wrapping it in a data frame method just for convenience:

import pandas as pd

def drop_prefix(self, prefix):
    self.columns = self.columns.str.lstrip(prefix)
    return self

pd.core.frame.DataFrame.drop_prefix = drop_prefix

Then you can use it as with inverse method already implemented in pandas add_prefix:

pd.drop_prefix('myprefix_')