• 具体错误为

D8: Cannot fit requested classes in a single dex file (# methods: 77376 > 65536)
com.android.builder.dexing.DexArchiveMergerException: Error while merging dex archives: 
The number of method references in a .dex file cannot exceed 64K.
Learn how to resolve this issue at https://developer.android.com/tools/building/multidex.html
	at com.android.builder.dexing.D8DexArchiveMerger.getExceptionToRethrow(D8DexArchiveMerger.java:132)
	at com.android.builder.dexing.D8DexArchiveMerger.mergeDexArchives(D8DexArchiveMerger.java:119)
	at com.android.build.gradle.internal.transforms.DexMergerTransformCallable.call(DexMergerTransformCallable.java:102)
	at com.android.build.gradle.internal.tasks.DexMergingTaskRunnable.run(DexMergingTask.kt:432)
	at com.android.build.gradle.internal.tasks.Workers$ActionFacade.run(Workers.kt:242)
	at org.gradle.workers.internal.AdapterWorkAction.execute(AdapterWorkAction.java:57)
	at org.gradle.workers.internal.DefaultWorkerServer.execute(DefaultWorkerServer.java:63)
	at org.gradle.workers.internal.NoIsolationWorkerFactory$1$1.create(NoIsolationWorkerFactory.java:67)
	at org.gradle.workers.internal.NoIsolationWorkerFactory$1$1.create(NoIsolationWorkerFactory.java:63)
	at org.gradle.internal.classloader.ClassLoaderUtils.executeInClassloader(ClassLoaderUtils.java:97)
	at org.gradle.workers.internal.NoIsolationWorkerFactory$1.lambda$execute$0(NoIsolationWorkerFactory.java:63)
	at org.gradle.workers.internal.AbstractWorker$1.call(AbstractWorker.java:44)
	at org.gradle.workers.internal.AbstractWorker$1.call(AbstractWorker.java:41)
	at org.gradle.internal.operations.DefaultBuildOperationExecutor$CallableBuildOperationWorker.execute(DefaultBuildOperationExecutor.java:409)
	at org.gradle.internal.operations.DefaultBuildOperationExecutor$CallableBuildOperationWorker.execute(DefaultBuildOperationExecutor.java:399)
	at org.gradle.internal.operations.DefaultBuildOperationExecutor$1.execute(DefaultBuildOperationExecutor.java:157)
	at org.gradle.internal.operations.DefaultBuildOperationExecutor.execute(DefaultBuildOperationExecutor.java:242)
	at org.gradle.internal.operations.DefaultBuildOperationExecutor.execute(DefaultBuildOperationExecutor.java:150)
	at org.gradle.internal.operations.DefaultBuildOperationExecutor.call(DefaultBuildOperationExecutor.java:94)
	at org.gradle.internal.operations.DelegatingBuildOperationExecutor.call(DelegatingBuildOperationExecutor.java:36)
	at org.gradle.workers.internal.AbstractWorker.executeWrappedInBuildOperation(AbstractWorker.java:41)
	at org.gradle.workers.internal.NoIsolationWorkerFactory$1.execute(NoIsolationWorkerFactory.java:60)
	at org.gradle.workers.internal.DefaultWorkerExecutor.lambda$submitWork$2(DefaultWorkerExecutor.java:200)
	at java.util.concurrent.FutureTask.run(FutureTask.java:266)
	at org.gradle.internal.work.DefaultConditionalExecutionQueue$ExecutionRunner.runExecution(DefaultConditionalExecutionQueue.java:215)
	at org.gradle.internal.work.DefaultConditionalExecutionQueue$ExecutionRunner.runBatch(DefaultConditionalExecutionQueue.java:164)
	at org.gradle.internal.work.DefaultConditionalExecutionQueue$ExecutionRunner.run(DefaultConditionalExecutionQueue.java:131)
	at java.util.concurrent.Executors$RunnableAdapter.call(Executors.java:511)
	at java.util.concurrent.FutureTask.run(FutureTask.java:266)
	at org.gradle.internal.concurrent.ExecutorPolicy$CatchAndRecordFailures.onExecute(ExecutorPolicy.java:64)
	at org.gradle.internal.concurrent.ManagedExecutorImpl$1.run(ManagedExecutorImpl.java:48)
	at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1149)
	at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:624)
	at org.gradle.internal.concurrent.ThreadFactoryImpl$ManagedThreadRunnable.run(ThreadFactoryImpl.java:56)
	at java.lang.Thread.run(Thread.java:748)
Caused by: com.android.tools.r8.CompilationFailedException: Compilation failed to complete, position: null
	at Version.fakeStackEntry(Version_2.1.86.java:0)
	at com.android.tools.r8.utils.Y.a(SourceFile:78)
	at com.android.tools.r8.D8.run(D8.java:11)
	at com.android.builder.dexing.D8DexArchiveMerger.mergeDexArchives(D8DexArchiveMerger.java:117)
	... 33 more
Caused by: com.android.tools.r8.utils.b: Cannot fit requested classes in a single dex file (# methods: 77376 > 65536)
	at com.android.tools.r8.utils.T0.error(SourceFile:1)
	at com.android.tools.r8.utils.T0.a(SourceFile:2)
	at com.android.tools.r8.dex.P.a(SourceFile:746)
	at com.android.tools.r8.dex.P$h.a(SourceFile:7)
	at com.android.tools.r8.dex.b.a(SourceFile:14)
	at com.android.tools.r8.dex.b.b(SourceFile:25)
	at com.android.tools.r8.D8.d(D8.java:133)
	at com.android.tools.r8.D8.b(D8.java:1)
	at com.android.tools.r8.utils.Y.a(SourceFile:36)
	... 35 more


FAILURE: Build failed with an exception.

* What went wrong:
Execution failed for task ':app:mergeDexDebug'.
> A failure occurred while executing com.android.build.gradle.internal.tasks.Workers$ActionFacade
   > com.android.builder.dexing.DexArchiveMergerException: Error while merging dex archives: 
     The number of method references in a .dex file cannot exceed 64K.
     Learn how to resolve this issue at https://developer.android.com/tools/building/multidex.html

* Try:
Run with --stacktrace option to get the stack trace. Run with --info or --debug option to get more log output. Run with --scan to get full insights.

* Get more help at https://help.gradle.org

BUILD FAILED in 44s
[!] The shrinker may have failed to optimize the Java bytecode.
    To disable the shrinker, pass the `--no-shrink` flag to this command.
    To learn more, see: https://developer.android.com/studio/build/shrink-code
Exception: Gradle task assembleDebug failed with exit code 1

解决方案

• 针对 MultiDex 配置应用
  • 因此，如果您的 minSdkVersion 设为 21 或更高版本，系统会默认启用 MultiDex，并且您不需要 - MultiDex 库。
  • 不过，如果您的 minSdkVersion 设为 20 或更低版本，您必须使用 MultiDex 库并对应用项目进行以下修改：
  • 修改模块级 build.gradle 文件以启用 MultiDex，并将 MultiDex 库添加为依赖项，如下所示：

android {
    defaultConfig {
        ...
        minSdkVersion 15
        targetSdkVersion 28
        // 添加这行
        multiDexEnabled true
    }
    ...
}

dependencies {
   // 添加这行
  implementation "androidx.multidex:multidex:2.0.1"
}

• 根据您是否替换 Application 类，执行以下某项操作：(我是直接没有替换Application, 更改的xml)
  • 如果您不替换 Application 类，请修改清单文件以设置 标记中的 android:name，如下所示：

<?xml version="1.0" encoding="utf-8"?>
<manifest xmlns:android="http://schemas.android.com/apk/res/android"
    package="com.example.myapp">
    <application
             // 修改这一行
            android:name="androidx.multidex.MultiDexApplication" >
        ...
    </application>
</manifest>

• 重新启动直接就可以了

参考方案

• android studio配置解决方案,为方法数超过 64K 的应用启用 MultiDex
• fluwx 其他最常见错误 直接参考issue