1、安装 libapache2-mod-python模块

sudo apt install libapache2-mod-python

2、站点启用Python支持

nano /etc/apache2/sites-available/000-default.conf

在VirtualHost设置的Directory设置内添加

AddHandler mod_python .py
PythonHandler mod_python.publisher
PythonDebug On

如：

<VirtualHost *:80>
	ServerName example.com
	ServerAlias www.example.com
	ServerAdmin service@example.com
	DocumentRoot /data/www/example.com
	<Directory />
		DirectoryIndex index.html index.php
		Options FollowSymLinks
		AllowOverride All

		#Rewrite
		RewriteEngine On

		#Python
		AddHandler mod_python .py
		PythonHandler mod_python.publisher
		PythonDebug On
	</Directory>

	ErrorLog /data/log/example_com_error.log
	CustomLog /data/log/example_com_access.log combined
</VirtualHost>

重启Apache2

service apache2 restart

测试，在网站根目录下新加文件test.py，输入内容

def index(req):
return "Hello World!";